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Ethoxyquin is a synthetic antioxidant (artificially manufactured from other elements) that is approved for different uses.
Ethoxyquin is approved and regulated by the Food and Drug Administration (FDA) and the Association of American Feed Control Officials (AAFCO) for use as a preservative in animal feeds.
Dog-food manufacturers have been using ethoxyquin to prevent rancidity and to maintain the nutritional quality of their products for more than 35 years.
Ethoxyquin remains stable at the high temperatures required to process dog foods during extrusion. It is important in protecting fats and oils from degrading, losing available calories, and becoming rancid.
Despite the fact that all studies conducted to date prove that ethoxyquin is safe for use in all animal foods when used at approved levels, rumors continue to circulate to the contrary.
Individuals who seek to discredit the use of ethoxyquin will often cite certain studies that showed toxic effects in animals fed ethoxyquin. What these individuals fail to point out is that the animals in these studies were given excessive amounts of ethoxyquin—20 to more than 50 times the maximum limit—before negative effects were exhibited.
Antioxidants are nutrients found naturally in the body and in plants such as fruits and vegetables. Common antioxidants include vitamin A, vitamin C, vitamin E, and certain compounds called carotenoids (like lutein and beta-carotene).
As cells function normally in the body, they produce damaged molecules called free radicals. These free radicals are highly unstable and steal components from other cellular molecules, such as fat, protein, or DNA, thereby spreading the damage.
This damage continues in a chain reaction, and entire cells soon become damaged and die. This process is called peroxidation. Peroxidation is useful because it helps the body destroy cells that have outlived their usefulness and kills germs and parasites. However, peroxidation, when left unchecked, also destroys or damages healthy cells.
Antioxidants help prevent widespread cellular destruction by stabilizing free radicals. More important, antioxidants return to the surface of the cell to stabilize, rather than damage, other cellular components.
When there are not enough antioxidants to keep peroxidation in check, free radicals begin damaging healthy cells, which, in turn, can lead to problems. For example, free-radical damage to cells of the immune system can lead to an increased risk of infections.
Because antioxidants play a key role in minimizing damage to human cells, such as those that make up the immune system, research examined the benefits of certain antioxidants on the immune response of dogs. The results of these studies indicated that antioxidants are important in helping dogs maintain a healthy immune system.
